Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer

[Image: see text] Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a number of anticancer drugs...

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Detalles Bibliográficos
Autores principales: Ando, Nozomi, Li, Haoran, Brignole, Edward J., Thompson, Samuel, McLaughlin, Martin I., Page, Julia E., Asturias, Francisco J., Stubbe, JoAnne, Drennan, Catherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722859/
https://www.ncbi.nlm.nih.gov/pubmed/26727048
http://dx.doi.org/10.1021/acs.biochem.5b01207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722859/
https://www.ncbi.nlm.nih.gov/pubmed/26727048
http://dx.doi.org/10.1021/acs.biochem.5b01207

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