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Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer
[Image: see text] Ribonucleotide reductases (RNRs) are responsible for all de novo biosynthesis of DNA precursors in nature by catalyzing the conversion of ribonucleotides to deoxyribonucleotides. Because of its essential role in cell division, human RNR is a target for a number of anticancer drugs...
Autores principales: | Ando, Nozomi, Li, Haoran, Brignole, Edward J., Thompson, Samuel, McLaughlin, Martin I., Page, Julia E., Asturias, Francisco J., Stubbe, JoAnne, Drennan, Catherine L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722859/ https://www.ncbi.nlm.nih.gov/pubmed/26727048 http://dx.doi.org/10.1021/acs.biochem.5b01207 |
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