Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase

Human 5-lipoxygenase (5-LOX) is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders. Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds, 3a and 3b, exhibiting a poten...

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Detalles Bibliográficos
Autores principales: Zhou, Yu, Liu, Jun, Zheng, Mingyue, Zheng, Shuli, Jiang, Chunyi, Zhou, Xiaomei, Zhang, Dong, Zhao, Jihui, Ye, Deju, Zheng, Mingfang, Jiang, Hualiang, Liu, Dongxiang, Cheng, Jian, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724694/
https://www.ncbi.nlm.nih.gov/pubmed/26904397
http://dx.doi.org/10.1016/j.apsb.2015.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724694/
https://www.ncbi.nlm.nih.gov/pubmed/26904397
http://dx.doi.org/10.1016/j.apsb.2015.11.004

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