Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases

[Image: see text] Members of the same protease family show different substrate specificity, even if they share identical folds, depending on the physiological processes they are part of. Here, we investigate the key factors for subpocket and global specificity of factor Xa, elastase, and granzyme B...

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Detalles Bibliográficos
Autores principales: Waldner, Birgit J., Fuchs, Julian E., Huber, Roland G., von Grafenstein, Susanne, Schauperl, Michael, Kramer, Christian, Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724848/
https://www.ncbi.nlm.nih.gov/pubmed/26709959
http://dx.doi.org/10.1021/acs.jpcb.5b10637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724848/
https://www.ncbi.nlm.nih.gov/pubmed/26709959
http://dx.doi.org/10.1021/acs.jpcb.5b10637

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