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Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion

AIMS: MMPs contribute to atherosclerotic plaque progression and instability, but the relative potency of their endogenous tissue inhibitors of metalloproteinases (TIMPs) as protective factors has not been defined. We therefore investigated the impact of TIMP-1 and TIMP-2 knockout on atherosclerotic...

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Detalles Bibliográficos
Autores principales: Di Gregoli, Karina, George, Sarah J., Jackson, Christopher L., Newby, Andrew C., Johnson, Jason L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724937/
https://www.ncbi.nlm.nih.gov/pubmed/26645981
http://dx.doi.org/10.1093/cvr/cvv268