Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming

Adenoviral early region 1A (E1A) is a viral gene that can promote cellular proliferation and de-differentiation in mammalian cells, features required for the reprogramming of somatic cells to a pluripotent state. E1A has been shown to interact with OCT4, and as a consequence, to increase OCT4 transc...

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Detalles Bibliográficos
Autores principales: Marthaler, Adele G., Adachi, Kenjiro, Tiemann, Ulf, Wu, Guangming, Sabour, Davood, Velychko, Sergiy, Kleiter, Ingo, Schöler, Hans R., Tapia, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725906/
https://www.ncbi.nlm.nih.gov/pubmed/26762895
http://dx.doi.org/10.1038/srep19415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725906/
https://www.ncbi.nlm.nih.gov/pubmed/26762895
http://dx.doi.org/10.1038/srep19415

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