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α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane

Fibrillar aggregates involved in neurodegenerative diseases have the ability to spread from one cell to another in a prion-like manner. The underlying molecular mechanisms, in particular the binding mode of the fibrils to cell membranes, are poorly understood. In this work we decipher the modality b...

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Detalles Bibliográficos
Autores principales: Monsellier, Elodie, Bousset, Luc, Melki, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725933/
https://www.ncbi.nlm.nih.gov/pubmed/26757959
http://dx.doi.org/10.1038/srep19180