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Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice

The involvement of systemic immunity in depression pathogenesis promises a periphery-targeting paradigm in novel anti-depressant discovery. However, relatively little is known about druggable targets in the periphery for mental and behavioral control. Here we report that targeting Ly6C(hi) monocytes...

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Detalles Bibliográficos
Autores principales: Zheng, Xiao, Ma, Sijing, Kang, An, Wu, Mengqiu, Wang, Lin, Wang, Qiong, Wang, Guangji, Hao, Haiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725984/
https://www.ncbi.nlm.nih.gov/pubmed/26783261
http://dx.doi.org/10.1038/srep19406