Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples

Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensiv...

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Autores principales: Bispo, Vanderson S., de Arruda Campos, Ivan P., Di Mascio, Paolo, Medeiros, Marisa H. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726056/
https://www.ncbi.nlm.nih.gov/pubmed/26783107
http://dx.doi.org/10.1038/srep19348
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author Bispo, Vanderson S.
de Arruda Campos, Ivan P.
Di Mascio, Paolo
Medeiros, Marisa H. G.
author_facet Bispo, Vanderson S.
de Arruda Campos, Ivan P.
Di Mascio, Paolo
Medeiros, Marisa H. G.
author_sort Bispo, Vanderson S.
collection PubMed
description Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 ± 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic strategies for carnosine.
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spelling pubmed-47260562016-01-28 Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples Bispo, Vanderson S. de Arruda Campos, Ivan P. Di Mascio, Paolo Medeiros, Marisa H. G. Sci Rep Article Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 ± 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic strategies for carnosine. Nature Publishing Group 2016-01-19 /pmc/articles/PMC4726056/ /pubmed/26783107 http://dx.doi.org/10.1038/srep19348 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bispo, Vanderson S.
de Arruda Campos, Ivan P.
Di Mascio, Paolo
Medeiros, Marisa H. G.
Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples
title Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples
title_full Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples
title_fullStr Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples
title_full_unstemmed Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples
title_short Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples
title_sort structural elucidation of a carnosine-acrolein adduct and its quantification in human urine samples
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726056/
https://www.ncbi.nlm.nih.gov/pubmed/26783107
http://dx.doi.org/10.1038/srep19348
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