The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels

Voltage-gated potassium (Kv) channels are essential for setting neuronal membrane excitability. Mutations in human Kv1.1 channels are linked to episodic ataxia type 1 (EA1). The EA1-associated mutation I262T was identified from a patient with atypical phenotypes. Although a previous report has chara...

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Detalles Bibliográficos
Autores principales: Chen, Szu-Han, Fu, Ssu-Ju, Huang, Jing-Jia, Tang, Chih-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726062/
https://www.ncbi.nlm.nih.gov/pubmed/26778656
http://dx.doi.org/10.1038/srep19378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726062/
https://www.ncbi.nlm.nih.gov/pubmed/26778656
http://dx.doi.org/10.1038/srep19378

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