Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α(18)

High replicative fitness is a general determinant of a multidrug resistance phenotype and may explain lower sensitivity to direct-acting antiviral agents (DAAs) in some hepatitis C virus genotypes. Genetic diversity in the molecular target site of peptidomimetic NS3 protease inhibitors could impact...

Descripción completa

Detalles Bibliográficos
Autores principales: Stross, Claudia, Shimakami, Tetsuro, Haselow, Katrin, Ahmad, Monazza Q., Zeuzem, Stefan, Lange, Christian M., Welsch, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726148/
https://www.ncbi.nlm.nih.gov/pubmed/26787124
http://dx.doi.org/10.1038/srep19526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726148/
https://www.ncbi.nlm.nih.gov/pubmed/26787124
http://dx.doi.org/10.1038/srep19526

Ejemplares similares