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Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α(18)

High replicative fitness is a general determinant of a multidrug resistance phenotype and may explain lower sensitivity to direct-acting antiviral agents (DAAs) in some hepatitis C virus genotypes. Genetic diversity in the molecular target site of peptidomimetic NS3 protease inhibitors could impact...

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Detalles Bibliográficos
Autores principales:	Stross, Claudia, Shimakami, Tetsuro, Haselow, Katrin, Ahmad, Monazza Q., Zeuzem, Stefan, Lange, Christian M., Welsch, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726148/ https://www.ncbi.nlm.nih.gov/pubmed/26787124 http://dx.doi.org/10.1038/srep19526

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