DNMT3L enables accumulation and inheritance of epimutations in transgenic Drosophila

DNMT3L is an important epigenetic regulator in mammals, integrating DNA methylation and histone modification based epigenetic circuits. Here we show DNMT3L to be a part of the machinery that enables inheritance of epigenetic modifications from one generation to the next. Ectopic expression of DNMT3L...

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Detalles Bibliográficos
Autores principales: Basu, Amitava, Tomar, Archana, Dasari, Vasanthi, Mishra, Rakesh Kumar, Khosla, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726149/
https://www.ncbi.nlm.nih.gov/pubmed/26795243
http://dx.doi.org/10.1038/srep19572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726149/
https://www.ncbi.nlm.nih.gov/pubmed/26795243
http://dx.doi.org/10.1038/srep19572

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