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Mechanisms Restricting Diffusion of Intracellular cAMP

Although numerous receptors stimulate cAMP production in a wide array of cells, many elicit distinct, highly localized responses, implying that the subcellular distribution of cAMP is not uniform. One often used explanation is that phosphodiesterases, which breakdown cAMP, act as functional barriers...

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Detalles Bibliográficos
Autores principales: Agarwal, Shailesh R., Clancy, Colleen E., Harvey, Robert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726171/
https://www.ncbi.nlm.nih.gov/pubmed/26795432
http://dx.doi.org/10.1038/srep19577