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Mechanism of substrate recognition by the novel Botulinum Neurotoxin subtype F5

Botulinum Neurotoxins (BoNTs) are the causative agents of botulism, which act by potently inhibiting the neurotransmitter release in motor neurons. Seven serotypes of BoNTs designated as BoNT/A-G have been identified. Recently, two novel types of Botulinum neurotoxins, which cleave a novel scissile...

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Detalles Bibliográficos
Autores principales: Guo, Jiubiao, Chan, Edward Wai Chi, Chen, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726221/
https://www.ncbi.nlm.nih.gov/pubmed/26794648
http://dx.doi.org/10.1038/srep19875