Functional mutagenesis screens reveal the ‘cap structure’ formation in disulfide-bridge free TASK channels

Two-pore-domain potassium (K(2P)) channels have a large extracellular cap structure formed by two M1-P1 linkers, containing a cysteine for dimerization. However, this cysteine is not present in the TASK-1/3/5 subfamily. The functional role of the cap is poorly understood and it remained unclear whet...

Descripción completa

Detalles Bibliográficos
Autores principales: Goldstein, Matthias, Rinné, Susanne, Kiper, Aytug K., Ramírez, David, Netter, Michael F., Bustos, Daniel, Ortiz-Bonnin, Beatriz, González, Wendy, Decher, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726246/
https://www.ncbi.nlm.nih.gov/pubmed/26794006
http://dx.doi.org/10.1038/srep19492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726246/
https://www.ncbi.nlm.nih.gov/pubmed/26794006
http://dx.doi.org/10.1038/srep19492

Ejemplares similares