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Functional mutagenesis screens reveal the ‘cap structure’ formation in disulfide-bridge free TASK channels

Two-pore-domain potassium (K(2P)) channels have a large extracellular cap structure formed by two M1-P1 linkers, containing a cysteine for dimerization. However, this cysteine is not present in the TASK-1/3/5 subfamily. The functional role of the cap is poorly understood and it remained unclear whet...

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Detalles Bibliográficos
Autores principales:	Goldstein, Matthias, Rinné, Susanne, Kiper, Aytug K., Ramírez, David, Netter, Michael F., Bustos, Daniel, Ortiz-Bonnin, Beatriz, González, Wendy, Decher, Niels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726246/ https://www.ncbi.nlm.nih.gov/pubmed/26794006 http://dx.doi.org/10.1038/srep19492

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