Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice

Loss of MeCP2 (Methyl CpG binding protein 2) in Rett syndrome (RTT) causes brain weight decrease, shrinkage of the cortex with reduced dendritic arborization, behavioral abnormalities, seizures and cardio-respiratory complications. The observed monoamine neurotransmitters reduction in RTT suggested...

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Detalles Bibliográficos
Autores principales: Bittolo, Tamara, Raminelli, Carlo Antonio, Deiana, Chiara, Baj, Gabriele, Vaghi, Valentina, Ferrazzo, Sara, Bernareggi, Annalisa, Tongiorgi, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726391/
https://www.ncbi.nlm.nih.gov/pubmed/26806603
http://dx.doi.org/10.1038/srep19796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726391/
https://www.ncbi.nlm.nih.gov/pubmed/26806603
http://dx.doi.org/10.1038/srep19796

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