Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells: Implication in Diabetic Nephropathy

Altered nucleoside levels may be linked to pathogenic signaling through adenosine receptors. We hypothesized that adenosine dysregulation contributes to fibrosis in diabetic kidney disease. Our findings indicate that high glucose levels and experimental diabetes decreased uptake activity through the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kretschmar, Catalina, Oyarzún, Carlos, Villablanca, Cristopher, Jaramillo, Catherinne, Alarcón, Sebastián, Perez, Gustavo, Díaz-Encarnación, Montserrat M., Pastor-Anglada, Marçal, Garrido, Wallys, Quezada, Claudia, San Martín, Rody
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726618/
https://www.ncbi.nlm.nih.gov/pubmed/26808537
http://dx.doi.org/10.1371/journal.pone.0147430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726618/
https://www.ncbi.nlm.nih.gov/pubmed/26808537
http://dx.doi.org/10.1371/journal.pone.0147430

Ejemplares similares