Cargando…

Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells: Implication in Diabetic Nephropathy

Altered nucleoside levels may be linked to pathogenic signaling through adenosine receptors. We hypothesized that adenosine dysregulation contributes to fibrosis in diabetic kidney disease. Our findings indicate that high glucose levels and experimental diabetes decreased uptake activity through the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kretschmar, Catalina, Oyarzún, Carlos, Villablanca, Cristopher, Jaramillo, Catherinne, Alarcón, Sebastián, Perez, Gustavo, Díaz-Encarnación, Montserrat M., Pastor-Anglada, Marçal, Garrido, Wallys, Quezada, Claudia, San Martín, Rody
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726618/ https://www.ncbi.nlm.nih.gov/pubmed/26808537 http://dx.doi.org/10.1371/journal.pone.0147430

Ejemplares similares

Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy
por: Alarcón, Sebastián, et al.
Publicado: (2017)

Author Correction: Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy
por: Alarcón, Sebastián, et al.
Publicado: (2020)

Blockade of the Adenosine A(3) Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats
por: Garrido, Wallys, et al.
Publicado: (2019)

Who Is Who in Adenosine Transport
por: Pastor-Anglada, Marçal, et al.
Publicado: (2018)

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage–Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A(2B) Adenosine Receptor
por: Torres, Ángelo, et al.
Publicado: (2020)

Adenosine A(3) receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells
por: Torres, Angelo, et al.
Publicado: (2016)

From Inflammation to the Onset of Fibrosis through A(2A) Receptors in Kidneys from Deceased Donors
por: Guillén-Gómez, Elena, et al.
Publicado: (2020)

Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells
por: Hu, Junping, et al.
Publicado: (2017)

Insights into the Pharmacogenetics of Tacrolimus Pharmacokinetics and Pharmacodynamics
por: Brunet, Mercè, et al.
Publicado: (2022)

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets
por: Pastor-Anglada, Marçal, et al.
Publicado: (2015)

Emerging Roles of Nucleoside Transporters
por: Pastor-Anglada, Marçal, et al.
Publicado: (2018)

Long Term Endocrine Regulation of Nucleoside Transporters in Rat Intestinal Epithelial Cells
por: Aymerich, Ivette, et al.
Publicado: (2004)

Mechanisms Implicated in the Response of System A to Hypertonic Stress and Amino Acid Deprivation Still Can Be Different
por: Pastor-Anglada, Marçal, et al.
Publicado: (2005)

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs
por: Pérez-Torras, Sandra, et al.
Publicado: (2012)

Inborn Errors of Nucleoside Transporter (NT)-Encoding Genes (SLC28 and SLC29)
por: Pastor-Anglada, Marçal, et al.
Publicado: (2022)

Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells
por: Alarcón, Sebastián, et al.
Publicado: (2020)

Mechanical regulation of cardiac fibroblast profibrotic phenotypes
por: Herum, Kate M., et al.
Publicado: (2017)

Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma
por: Peña-Oyarzún, Daniel, et al.
Publicado: (2020)

A(2B) Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New Insights into MRP3 Transporter Function
por: Rocha, José-Dellis, et al.
Publicado: (2022)

Urinary Markers of Tubular Injury in Early Diabetic Nephropathy
por: Fiseha, Temesgen, et al.
Publicado: (2016)

Hyperosmotic stress stimulates autophagy via polycystin-2
por: Peña-Oyarzun, Daniel, et al.
Publicado: (2017)

Profibrotic pathways and atrial cardiomyopathy in persistent atrial fibrillation
por: Canpolat, Uğur
Publicado: (2016)

Profibrotic mediators in tendon disease: a systematic review
por: Morita, Wataru, et al.
Publicado: (2016)

Adenosine monophosphate–activated protein kinase in diabetic nephropathy
por: Kim, Yaeni, et al.
Publicado: (2016)

Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness
por: Niechi, Ignacio, et al.
Publicado: (2019)

The Adenosine A(3) Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia
por: Rocha, René, et al.
Publicado: (2018)

Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications
por: López-Novoa, José M, et al.
Publicado: (2011)

Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy
por: Xiao, Li, et al.
Publicado: (2014)

Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
por: Sun, Jia, et al.
Publicado: (2017)

Direct evidence of proximal tubular proliferation in early diabetic nephropathy
por: Uehara-Watanabe, Noriko, et al.
Publicado: (2022)

The Osmoregulatory and the Amino Acid-regulated Responses of System A Are Mediated by Different Signal Transduction Pathways
por: López-Fontanals, Marta, et al.
Publicado: (2003)

IL-13 induces a bronchial epithelial phenotype that is profibrotic
por: Malavia, Nikita K, et al.
Publicado: (2008)

Profibrotic epithelial phenotype: a central role for MRTF and TAZ
por: Bialik, Janne Folke, et al.
Publicado: (2019)

Inhibition of profibrotic microRNA-21 affects platelets and their releasate
por: Barwari, Temo, et al.
Publicado: (2018)

Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis
por: Zhang, Fenghua, et al.
Publicado: (2020)

Role of drug-dependent transporter modulation on the chemosensitivity of cholangiocarcinoma
por: Urtasun, Nerea, et al.
Publicado: (2017)

Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin
por: Burgy, Olivier, et al.
Publicado: (2016)

Urinary Cystatin C and Tubular Proteinuria Predict Progression of Diabetic Nephropathy
por: Kim, Sang Soo, et al.
Publicado: (2013)

Lysine Acetylation in the Proteome of Renal Tubular Epithelial Cells in Diabetic Nephropathy
por: Wan, Jiayi, et al.
Publicado: (2021)

Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy
por: Wong, D W L, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_40hlkod70ubl73a0pl1nu8lt8k