Flexibility and small pockets at protein–protein interfaces: New insights into druggability

The transient assembly of multiprotein complexes mediates many aspects of cell regulation and signalling in living organisms. Modulation of the formation of these complexes through targeting protein–protein interfaces can offer greater selectivity than the inhibition of protein kinases, proteases or...

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Detalles Bibliográficos
Autores principales: Jubb, Harry, Blundell, Tom L., Ascher, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726663/
https://www.ncbi.nlm.nih.gov/pubmed/25662442
http://dx.doi.org/10.1016/j.pbiomolbio.2015.01.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726663/
https://www.ncbi.nlm.nih.gov/pubmed/25662442
http://dx.doi.org/10.1016/j.pbiomolbio.2015.01.009

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