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Flexibility and small pockets at protein–protein interfaces: New insights into druggability
The transient assembly of multiprotein complexes mediates many aspects of cell regulation and signalling in living organisms. Modulation of the formation of these complexes through targeting protein–protein interfaces can offer greater selectivity than the inhibition of protein kinases, proteases or...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Pergamon Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726663/ https://www.ncbi.nlm.nih.gov/pubmed/25662442 http://dx.doi.org/10.1016/j.pbiomolbio.2015.01.009 |