Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells

Polyphyllin VII (PP7), a pennogenyl saponin isolated from Rhizoma Paridis, exhibited strong anticancer activities in various cancer types. Previous studies found that PP7 induced apoptotic cell death in human hepatoblastoma cancer (HepG2) cells. In the present study, we investigated whether PP7 coul...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Li, Peng, Chen, Meiwan, Wan, Jian-Bo, Su, Huanxing, Mei, Zhinan, He, Chengwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726701/
https://www.ncbi.nlm.nih.gov/pubmed/26808193
http://dx.doi.org/10.1371/journal.pone.0147405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726701/
https://www.ncbi.nlm.nih.gov/pubmed/26808193
http://dx.doi.org/10.1371/journal.pone.0147405

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