Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling

BACKGROUND: The endoplasmic reticulum (ER) plays an essential role in ensuring proper folding of the newly synthesized proteins. Aberrant ER homeostasis triggers ER stress and development of cardiovascular diseases. ADH is involved in catalyzing ethanol to acetaldehyde although its role in cardiovas...

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Detalles Bibliográficos
Autores principales: Pang, Jiaojiao, Fuller, Nathan D., Hu, Nan, Barton, Linzi A., Henion, Jeremy M., Guo, Rui, Chen, Yuguo, Ren, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726758/
https://www.ncbi.nlm.nih.gov/pubmed/26807981
http://dx.doi.org/10.1371/journal.pone.0147322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726758/
https://www.ncbi.nlm.nih.gov/pubmed/26807981
http://dx.doi.org/10.1371/journal.pone.0147322

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