Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature

Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect the epigenetic regulatory machinery and signaling molecules, leading to a block in hematopoietic differentiation. Constitutive signaling from mutated growth factor receptors is a major driver of leukemic growth, but how...

Descripción completa

Detalles Bibliográficos
Autores principales: Cauchy, Pierre, James, Sally R., Zacarias-Cabeza, Joaquin, Ptasinska, Anetta, Imperato, Maria Rosaria, Assi, Salam A., Piper, Jason, Canestraro, Martina, Hoogenkamp, Maarten, Raghavan, Manoj, Loke, Justin, Akiki, Susanna, Clokie, Samuel J., Richards, Stephen J., Westhead, David R., Griffiths, Michael J., Ott, Sascha, Bonifer, Constanze, Cockerill, Peter N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726916/
https://www.ncbi.nlm.nih.gov/pubmed/26212328
http://dx.doi.org/10.1016/j.celrep.2015.06.069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726916/
https://www.ncbi.nlm.nih.gov/pubmed/26212328
http://dx.doi.org/10.1016/j.celrep.2015.06.069

Ejemplares similares