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A pivot mutation impedes reverse evolution across an adaptive landscape for drug resistance in Plasmodium vivax
BACKGROUND: The study of reverse evolution from resistant to susceptible phenotypes can reveal constraints on biological evolution, a topic for which evolutionary theory has relatively few general principles. The public health catastrophe of antimicrobial resistance in malaria has brought these cons...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727274/ https://www.ncbi.nlm.nih.gov/pubmed/26809718 http://dx.doi.org/10.1186/s12936-016-1090-3 |