Loss of nuclear localization of TET2 in colorectal cancer

5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Her...

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Autores principales: Huang, Yuji, Wang, Guanghui, Liang, Zhonglin, Yang, Yili, Cui, Long, Liu, Chen-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727298/
https://www.ncbi.nlm.nih.gov/pubmed/26816554
http://dx.doi.org/10.1186/s13148-016-0176-7
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author Huang, Yuji
Wang, Guanghui
Liang, Zhonglin
Yang, Yili
Cui, Long
Liu, Chen-Ying
author_facet Huang, Yuji
Wang, Guanghui
Liang, Zhonglin
Yang, Yili
Cui, Long
Liu, Chen-Ying
author_sort Huang, Yuji
collection PubMed
description 5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13148-016-0176-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-47272982016-01-27 Loss of nuclear localization of TET2 in colorectal cancer Huang, Yuji Wang, Guanghui Liang, Zhonglin Yang, Yili Cui, Long Liu, Chen-Ying Clin Epigenetics Letter to the Editor 5-Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but not other two TET family members, has been observed in the colorectal cancer and is crucial for colorectal cancer initiation. Here, we show that nuclear localization of TET2 was lost in a significant portion of CRC tissues, in association with metastasis. In CRC cells, nuclear expression of TET2 were absent but not TET3. Nuclear export inhibitor can increase the 5hmC level in CRC cells, probably through regulating TET2. Our results indicate a new mechanism of TET2 dysregulation in colorectal cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13148-016-0176-7) contains supplementary material, which is available to authorized users. BioMed Central 2016-01-26 /pmc/articles/PMC4727298/ /pubmed/26816554 http://dx.doi.org/10.1186/s13148-016-0176-7 Text en © Huang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Huang, Yuji
Wang, Guanghui
Liang, Zhonglin
Yang, Yili
Cui, Long
Liu, Chen-Ying
Loss of nuclear localization of TET2 in colorectal cancer
title Loss of nuclear localization of TET2 in colorectal cancer
title_full Loss of nuclear localization of TET2 in colorectal cancer
title_fullStr Loss of nuclear localization of TET2 in colorectal cancer
title_full_unstemmed Loss of nuclear localization of TET2 in colorectal cancer
title_short Loss of nuclear localization of TET2 in colorectal cancer
title_sort loss of nuclear localization of tet2 in colorectal cancer
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727298/
https://www.ncbi.nlm.nih.gov/pubmed/26816554
http://dx.doi.org/10.1186/s13148-016-0176-7
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AT yangyili lossofnuclearlocalizationoftet2incolorectalcancer
AT cuilong lossofnuclearlocalizationoftet2incolorectalcancer
AT liuchenying lossofnuclearlocalizationoftet2incolorectalcancer

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