Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase

INTRODUCTION: The motor system is selectively vulnerable to mutations in the ubiquitously expressed aggregation-prone enzyme superoxide dismutase-1 (SOD1). RESULTS: Autophagy clears aggregates, and factors involved in the process were analyzed in multiple areas of the CNS from human control subjects...

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Detalles Bibliográficos
Autores principales: Tokuda, Eiichi, Brännström, Thomas, Andersen, Peter M., Marklund, Stefan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727314/
https://www.ncbi.nlm.nih.gov/pubmed/26810478
http://dx.doi.org/10.1186/s40478-016-0274-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727314/
https://www.ncbi.nlm.nih.gov/pubmed/26810478
http://dx.doi.org/10.1186/s40478-016-0274-y

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