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Integrating mutation and gene expression cross-sectional data to infer cancer progression

BACKGROUND: A major problem in identifying the best therapeutic targets for cancer is the molecular heterogeneity of the disease. Cancer is often caused by an accumulation of mutations which produce irreversible damage to the cell’s control mechanisms of survival and proliferation. Different mutatio...

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Detalles Bibliográficos
Autores principales: Fleck, Julia L., Pavel, Ana B., Cassandras, Christos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727329/
https://www.ncbi.nlm.nih.gov/pubmed/26810975
http://dx.doi.org/10.1186/s12918-016-0255-6