Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress

BACKGROUND: Human induced pluripotent stem (hiPS) cells have the ability to undergo self-renewal and differentiation similarly to human embryonic stem (hES) cells. We have recently shown that hES cells under replication stress fail to activate checkpoint kinase 1 (CHK1). They instead commit to apopt...

Descripción completa

Detalles Bibliográficos
Autores principales: Desmarais, Joelle A., Unger, Christian, Damjanov, Ivan, Meuth, Mark, Andrews, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727355/
https://www.ncbi.nlm.nih.gov/pubmed/26810087
http://dx.doi.org/10.1186/s13287-016-0279-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727355/
https://www.ncbi.nlm.nih.gov/pubmed/26810087
http://dx.doi.org/10.1186/s13287-016-0279-2

Ejemplares similares