P2Y12 antagonist attenuates eosinophilic inflammation and airway hyperresponsiveness in a mouse model of asthma

Leukotriene E4 (LTE4) that plays a key role in airway inflammation is expressed on platelets and eosinophils. We investigated whether blocking of the P2Y12 receptor can suppress eosinophilic inflammation in a mouse model of asthma because platelets and eosinophils share this receptor to be activated...

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Detalles Bibliográficos
Autores principales: Suh, Dong‐Hyeon, Trinh, Hoang Kim Tu, Liu, Jing‐Nan, Pham, Le Duy, Park, Sang Myun, Park, Hae‐Sim, Shin, Yoo Seob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727565/
https://www.ncbi.nlm.nih.gov/pubmed/26612496
http://dx.doi.org/10.1111/jcmm.12727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727565/
https://www.ncbi.nlm.nih.gov/pubmed/26612496
http://dx.doi.org/10.1111/jcmm.12727

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