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Synthesis of Isomeric and Potent Impurities of the Triazole-Based Antifungal Drug Voriconazole
We describe the synthesis of two positional isomers and a desfluoro impurity of Voriconazole starting with Friedel–Crafts acylation of mono- and difluorobenzene. These isomers are the crucial components in determining the quality of Voriconazole during its manufacturing from the key raw material, 1-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Austrian Journal of Pharmaceutical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727777/ https://www.ncbi.nlm.nih.gov/pubmed/26839829 http://dx.doi.org/10.3797/scipharm.1501-13 |