Cargando…

Synthesis of Isomeric and Potent Impurities of the Triazole-Based Antifungal Drug Voriconazole

We describe the synthesis of two positional isomers and a desfluoro impurity of Voriconazole starting with Friedel–Crafts acylation of mono- and difluorobenzene. These isomers are the crucial components in determining the quality of Voriconazole during its manufacturing from the key raw material, 1-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sundaram, Dhanraj T. S. S., Mitra, Jayati, Islam, Aminul, Prabahar, Koilpillai Joseph, Venkateswara Rao, Battula, Paul Douglas, Sanasi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Austrian Journal of Pharmaceutical Sciences 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727777/ https://www.ncbi.nlm.nih.gov/pubmed/26839829 http://dx.doi.org/10.3797/scipharm.1501-13

Ejemplares similares

An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir
por: Sundaram, Dhanraj T. S. S., et al.
Publicado: (2015)

Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug
por: Garaga, Srinivas, et al.
Publicado: (2013)

Study on Isomeric Impurities in Cefotiam Hydrochloride
por: Tian, Ye, et al.
Publicado: (2021)

Design, synthesis and in vitro biological studies of novel triazoles with potent and broad-spectrum antifungal activity
por: Bao, Junhe, et al.
Publicado: (2023)

The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance
por: Mroczyńska, Martyna, et al.
Publicado: (2020)

A Validated Stability-Indicating Liquid Chromatographic Method for Determination of Degradation Impurities and Diastereomers in Voriconazole Tablets
por: Shaikh, Kabeer A., et al.
Publicado: (2012)

Antifungal management in ICU: careful follow-up of voriconazole prescription needed!
por: Reizine, Florian, et al.
Publicado: (2023)

Cost-effectiveness analysis of combination antifungal therapy with voriconazole and anidulafungin versus voriconazole monotherapy for primary treatment of invasive aspergillosis in Spain
por: Grau, Santiago, et al.
Publicado: (2016)

Hazard of agricultural triazole fungicide: Does cyproconazole induce voriconazole resistance in Aspergillus fumigatus isolates?
por: Moazeni, Maryam, et al.
Publicado: (2020)

Antifungal wound penetration of amphotericin and voriconazole in combat-related injuries: case report
por: Akers, Kevin S, et al.
Publicado: (2015)

Molecular and cellular responses of the pathogenic fungus Lomentospora prolificans to the antifungal drug voriconazole
por: Pellon, Aize, et al.
Publicado: (2017)

Fabrication and Evaluation of Voriconazole Loaded Transethosomal Gel for Enhanced Antifungal and Antileishmanial Activity
por: Farooq, Mudassir, et al.
Publicado: (2022)

Comparison of the antifungal effect of voriconazole and fluconazole on oral candidiasis before and during radiotherapy
por: Golestannejad, Zahra, et al.
Publicado: (2022)

Advances in synthetic approach to and antifungal activity of triazoles
por: Shalini, Kumari, et al.
Publicado: (2011)

Design, Synthesis, and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents
por: Sadeghpour, Hossein, et al.
Publicado: (2017)

The Positional Isomeric Effect on the Structural Diversity of Cd(II) Coordination Polymers, Using Flexible Positional Isomeric Ligands Containing Pyridyl, Triazole, and Carboxylate Fragments
por: Cisterna, Jonathan, et al.
Publicado: (2018)

Flaws in design, analysis and interpretation of Pfizer's antifungal trials of voriconazole and uncritical subsequent quotations
por: Jørgensen, Karsten J, et al.
Publicado: (2006)

Voriconazole versus itraconazole for antifungal prophylaxis following allogeneic haematopoietic stem-cell transplantation
por: Marks, David I, et al.
Publicado: (2011)

Evaluation of the synergistic antifungal activity of micafungin and voriconazole plus sertraline against Candida auris
por: Alanís-Ríos, Sergio A., et al.
Publicado: (2022)

Antifungal prophylactic effectiveness and intrapulmonary concentrations of voriconazole versus posaconazole in lung transplant recipients
por: Ju, Chunrong, et al.
Publicado: (2022)

Comparative study of posaconazole and voriconazole for primary antifungal prophylaxis in patients with pediatric acute leukemia
por: Tu, Songji, et al.
Publicado: (2023)

Novel 1, 2, 4-Triazoles as Antifungal Agents
por: Kazeminejad, Zahra, et al.
Publicado: (2022)

Profile susceptibility to fluconazole and voriconazole antifungals by species of Candida albicans isolated from urine culture
por: Wiebusch, Laura, et al.
Publicado: (2014)

Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole
por: Udawatte, Nadeeka S., et al.
Publicado: (2020)

755. Posaconazole versus voriconazole as antifungal prophylaxis for invasive fungal diseases in patients with hematological malignancies
por: Almutairy, Reem F, et al.
Publicado: (2020)

S9.2d Directed evolution of voriconazole resistance in Aspergillus fumigatus identifies novel mutations responsible for triazole resistance
por: Handelman, Mariana, et al.
Publicado: (2022)

Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
por: Liang, Zhen, et al.
Publicado: (2016)

818. Therapeutic Drug Monitoring of Triazole Antifungals for Coccidioidal Meningitis
por: Fang, Michelle, et al.
Publicado: (2023)

Eradication of Lomentospora prolificans Osteomyelitis of the Wrist with Combination Antifungal Therapy, Voriconazole Bone Cement, and Surgical Debridement
por: Lee, Jeremy, et al.
Publicado: (2020)

1291. Safety of Isavuconazole Compared with Voriconazole as Primary Antifungal Prophylaxis in Allogeneic Hematopoietic Cell Transplant Recipients
por: Bogler, Yael, et al.
Publicado: (2020)

Formulation Development, Characterization and Antifungal Evaluation of Chitosan NPs for Topical Delivery of Voriconazole In Vitro and Ex Vivo
por: Shah, Muhammad Khurshid Alam, et al.
Publicado: (2021)

Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection
por: Colley, Thomas, et al.
Publicado: (2019)

Triazole derivatives with improved in vitro antifungal activity over azole drugs
por: Yu, Shichong, et al.
Publicado: (2014)

Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety
por: Wang, Yanwei, et al.
Publicado: (2014)

Impure Water Makes Impure Ice
Publicado: (1882)

Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity
por: Veloso, Danillo F. M. C., et al.
Publicado: (2018)

Saliva for Precision Dosing of Antifungal Drugs: Saliva Population PK Model for Voriconazole Based on a Systematic Review.
por: Kim, Hannah Yejin, et al.
Publicado: (2020)

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles
por: Kammoun, Ahmed K., et al.
Publicado: (2021)

Isomeric Mono-, Di-, and Tri-Bromobenzo-1H-Triazoles as Inhibitors of Human Protein Kinase CK2α
por: Wąsik, Romualda, et al.
Publicado: (2012)

Efficacy of voriconazole and amphotericin B in corneal preservative media
por: Das, Sujata, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_78phri0cmr81ec6f6rro1osg9g