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Cost-Effective Isolation of a Process Impurity of Pregabalin
Cost-effective isolation methods were developed on preparative HPLC, flash LC, and simulated moving bed (SMB) to prepare the process impurity, 3-(aminomethyl)-5-methylhex-4-enoic acid (4-ene impurity), of pregabalin. By a thorough experimental study on the different isolation techniques available, i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Austrian Journal of Pharmaceutical Sciences
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727790/ https://www.ncbi.nlm.nih.gov/pubmed/26839830 http://dx.doi.org/10.3797/scipharm.1501-16 |