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RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages

Nuclear hormone receptors have important roles in the regulation of metabolic and inflammatory pathways. The retinoid-related orphan receptor alpha (Rorα)-deficient staggerer (sg/sg) mice display several phenotypes indicative of aberrant lipid metabolism, including dyslipidemia, and increased suscep...

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Detalles Bibliográficos
Autores principales: Tuong, Zewen Kelvin, Lau, Patrick, Du, Ximing, Condon, Nicholas D., Goode, Joel M., Oh, Tae Gyu, Yeo, Jeremy C., Muscat, George E. O., Stow, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727927/
https://www.ncbi.nlm.nih.gov/pubmed/26812621
http://dx.doi.org/10.1371/journal.pone.0147179