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Orai1 pore residues control CRAC channel inactivation independently of calmodulin
Ca(2+) entry through CRAC channels causes fast Ca(2+)-dependent inactivation (CDI). Previous mutagenesis studies have implicated Orai1 residues W76 and Y80 in CDI through their role in binding calmodulin (CaM), in agreement with the crystal structure of Ca(2+)–CaM bound to an Orai1 N-terminal peptid...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727942/ https://www.ncbi.nlm.nih.gov/pubmed/26809793 http://dx.doi.org/10.1085/jgp.201511437 |