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Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop
Pannexin1 (Panx1) is an ATP release channel important for controlling immune responses and synaptic strength. Various stimuli including C-terminal cleavage, a high concentration of extracellular potassium, and voltage have been demonstrated to activate Panx1. However, it remains unclear how Panx1 se...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727946/ https://www.ncbi.nlm.nih.gov/pubmed/26755773 http://dx.doi.org/10.1085/jgp.201511505 |