Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats

Background. This study was to explore the pharmacokinetics of saxagliptin (Sax) in Goto–Kakizaki (GK) rats complicated with depression induced by chronic unpredicted mild stress (CUMS). The comorbidity of diabetic patients with depression is becoming more and more epidemic. Whether depression mental...

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Detalles Bibliográficos
Autores principales: Xia, Zhengchao, Wei, Hongyan, Duan, Jingjing, Zhou, Ting, Yang, Zhen, Xu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727972/
https://www.ncbi.nlm.nih.gov/pubmed/26819853
http://dx.doi.org/10.7717/peerj.1611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727972/
https://www.ncbi.nlm.nih.gov/pubmed/26819853
http://dx.doi.org/10.7717/peerj.1611

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