Validation of a Multiplex Allele-Specific Polymerase Chain Reaction Assay for Detection of KRAS Gene Mutations in Formalin-Fixed, Paraffin-Embedded Tissues from Colorectal Cancer Patients

BACKGROUND: Patients with KRAS mutations do not respond to epidermal growth factor receptor (EGFR) inhibitors and fail to benefit from adjuvant chemotherapy. Mutation analysis of KRAS is needed before starting treatment with monoclonal anti-EGFR antibodies in patients with metastatic colorectal canc...

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Detalles Bibliográficos
Autores principales: Seekhuntod, Sirirat, Thavarungkul, Paninee, Chaichanawongsaroj, Nuntaree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728071/
https://www.ncbi.nlm.nih.gov/pubmed/26812617
http://dx.doi.org/10.1371/journal.pone.0147672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728071/
https://www.ncbi.nlm.nih.gov/pubmed/26812617
http://dx.doi.org/10.1371/journal.pone.0147672

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