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A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics
Microtubule dynamic instability depends on the GTPase activity of the polymerizing αβ-tubulin subunits, which cycle through at least three distinct conformations as they move into and out of microtubules. How this conformational cycle contributes to microtubule growing, shrinking, and switching rema...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728127/ https://www.ncbi.nlm.nih.gov/pubmed/26439009 http://dx.doi.org/10.7554/eLife.10113 |