Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells. We found that cytoplasmic IL-1β associates with the aut...

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Detalles Bibliográficos
Autores principales: Zhang, Min, Kenny, Samuel J, Ge, Liang, Xu, Ke, Schekman, Randy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728131/
https://www.ncbi.nlm.nih.gov/pubmed/26523392
http://dx.doi.org/10.7554/eLife.11205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728131/
https://www.ncbi.nlm.nih.gov/pubmed/26523392
http://dx.doi.org/10.7554/eLife.11205

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