Cargando…

PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility

Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway whi...

Descripción completa

Detalles Bibliográficos
Autores principales: González Wusener, Ana E., González, Ángela, Nakamura, Fumihiko, Arregui, Carlos O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728310/
https://www.ncbi.nlm.nih.gov/pubmed/26700725
http://dx.doi.org/10.1242/bio.015883