Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activa...

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Detalles Bibliográficos
Autores principales: Li, Guoxi, Zhou, Libin, Zhu, Ying, Wang, Conghui, Sha, Sha, Xian, Xunde, Ji, Yong, Liu, George, Chen, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728316/
https://www.ncbi.nlm.nih.gov/pubmed/26398946
http://dx.doi.org/10.1242/dmm.021550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728316/
https://www.ncbi.nlm.nih.gov/pubmed/26398946
http://dx.doi.org/10.1242/dmm.021550

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