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metilene: fast and sensitive calling of differentially methylated regions from bisulfite sequencing data

The detection of differentially methylated regions (DMRs) is a necessary prerequisite for characterizing different epigenetic states. We present a novel program, metilene, to identify DMRs within whole-genome and targeted data with unrivaled specificity and sensitivity. A binary segmentation algorit...

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Detalles Bibliográficos
Autores principales:	Jühling, Frank, Kretzmer, Helene, Bernhart, Stephan H., Otto, Christian, Stadler, Peter F., Hoffmann, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728377/ https://www.ncbi.nlm.nih.gov/pubmed/26631489 http://dx.doi.org/10.1101/gr.196394.115

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