Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P(1) and S1P(2) receptors

Herein we show that S1P rapidly and acutely reduces the focal adhesion strength and barrier tightness of brain endothelial cells. xCELLigence biosensor technology was used to measure focal adhesion, which was reduced by S1P acutely and this response was mediated through both S1P(1) and S1P(2) recept...

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Detalles Bibliográficos
Autores principales: Wiltshire, Rachael, Nelson, Vicky, Kho, Dan Ting, Angel, Catherine E., O’Carroll, Simon J., Graham, E. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728386/
https://www.ncbi.nlm.nih.gov/pubmed/26813587
http://dx.doi.org/10.1038/srep19814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728386/
https://www.ncbi.nlm.nih.gov/pubmed/26813587
http://dx.doi.org/10.1038/srep19814

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