Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47

Thrombospondin-1 regulates inflammation by engaging several cell surface receptors and by modulating activities of other secreted factors. We have uncovered a novel role of thrombospondin-1 in modulating production and activation of the proinflammatory cytokine IL-1β by human and murine macrophages....

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Detalles Bibliográficos
Autores principales: Stein, Erica V., Miller, Thomas W., Ivins-O’Keefe, Kelly, Kaur, Sukhbir, Roberts, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728557/
https://www.ncbi.nlm.nih.gov/pubmed/26813769
http://dx.doi.org/10.1038/srep19684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728557/
https://www.ncbi.nlm.nih.gov/pubmed/26813769
http://dx.doi.org/10.1038/srep19684

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