Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis

Inhibition of stearoyl-CoA desaturase 1 (SCD1) has been found to effectively suppress tumor cell proliferation and induce apoptosis in numerous neoplastic lesions. However, mechanism underlying SCD1-mediated anti-tumor effect has maintained unclear. Herein, we reported endo-lipid messenger ceramides...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ling, Ren, Jie, Yang, Longhe, Li, Yanting, Fu, Jin, Li, Yuhang, Tian, Yifeng, Qiu, Funan, Liu, Zuguo, Qiu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728559/
https://www.ncbi.nlm.nih.gov/pubmed/26813308
http://dx.doi.org/10.1038/srep19665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728559/
https://www.ncbi.nlm.nih.gov/pubmed/26813308
http://dx.doi.org/10.1038/srep19665

Ejemplares similares