NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector

The replication-incompetent adenovirus (Ad) vector is one of the most promising vectors for gene therapy; however, systemic administration of Ad vectors results in severe hepatotoxicities, partly due to the leaky expression of Ad genes in the liver. Here we show that nuclear factor-kappa B (NF-κB) m...

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Detalles Bibliográficos
Autores principales: Machitani, M., Sakurai, F., Wakabayashi, K., Nakatani, K., Shimizu, K., Tachibana, M., Mizuguchi, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728692/
https://www.ncbi.nlm.nih.gov/pubmed/26814140
http://dx.doi.org/10.1038/srep19922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728692/
https://www.ncbi.nlm.nih.gov/pubmed/26814140
http://dx.doi.org/10.1038/srep19922

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