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Simultaneous Determination and Pharmacokinetic Study of Losartan, Losartan Carboxylic Acid, Ramipril, Ramiprilat, and Hydrochlorothiazide in Rat Plasma by a Liquid Chromatography/Tandem Mass Spectrometry Method
The monitoring of the plasmatic concentrations of cardiovascular drugs is crucial for understanding their pharmacokinetics and pharmacodynamics. A simple, sensitive, specific, and high-throughput liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the sim...
Autores principales: | Dubey, Ramkumar, Ghosh, Manik |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Austrian Journal of Pharmaceutical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729183/ https://www.ncbi.nlm.nih.gov/pubmed/26839805 http://dx.doi.org/10.3797/scipharm.1410-15 |
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