Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes

Overexpression of Smad ubiquitin regulatory factor 2 (Smurf2) in chondrocytes was reported to cause spontaneous osteoarthritis (OA) in mice. However, it is unclear whether Smurf2 is involved in bone and cartilage homeostasis and if it is required for OA pathogenesis. Here we characterized age-relate...

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Detalles Bibliográficos
Autores principales: Huang, Henry, Veien, Eric S., Zhang, Hong, Ayers, David C., Song, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729489/
https://www.ncbi.nlm.nih.gov/pubmed/26815610
http://dx.doi.org/10.1371/journal.pone.0148088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729489/
https://www.ncbi.nlm.nih.gov/pubmed/26815610
http://dx.doi.org/10.1371/journal.pone.0148088

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